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Sympathetic innervation promotes vascular smooth muscle differentiation
American Journal of Physiology. Heart and Circulatory Physiology
The sympathetic nervous system (SNS) is an important modulator of vascular smooth muscle (VSM) growth and function. Several lines of evidence suggest that the SNS also promotes VSM differentiation. The present study tests this hypothesis. Expression of smooth muscle myosin (SM2) and ␣-actin were assessed by Western analysis as indexes of VSM differentiation. SM2 expression (normalized to ␣-actin) in adult innervated rat femoral and tail arteries was 479 Ϯ 115% of that in noninnervated carotiddoi:10.1152/ajpheart.00354.2004 pmid:15665063 fatcat:rmzjaxyzcnhkpmlo7pcxmfdcma