The Potential of Alkaline Phosphatase as a Treatment for Sepsis-Associated Acute Kidney Injury

Esther Peters, Rosalinde Masereeuw, Peter Pickkers
2014 Nephron Clinical Practice  
stress, which can be converted by alkaline phosphatase into the tissue-protective and anti-inflammatory molecule adenosine. Human recombinant alkaline phosphatase, a recently developed replacement for bovine-derived alkaline phosphatase, has shown promising results in the preclinical phase. As its safety and tolerability were recently confirmed in a phase I clinical trial, the renal protective effect of human recombinant alkaline phosphatase in sepsis-associated AKI shall be investigated in a
more » ... lticenter phase II clinical trial starting at the end of this year.
doi:10.1159/000363256 pmid:25343839 fatcat:to6cz3mchne4lo2nxqiqqvs2vi