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The Potential of Alkaline Phosphatase as a Treatment for Sepsis-Associated Acute Kidney Injury
2014
Nephron Clinical Practice
stress, which can be converted by alkaline phosphatase into the tissue-protective and anti-inflammatory molecule adenosine. Human recombinant alkaline phosphatase, a recently developed replacement for bovine-derived alkaline phosphatase, has shown promising results in the preclinical phase. As its safety and tolerability were recently confirmed in a phase I clinical trial, the renal protective effect of human recombinant alkaline phosphatase in sepsis-associated AKI shall be investigated in a
doi:10.1159/000363256
pmid:25343839
fatcat:to6cz3mchne4lo2nxqiqqvs2vi