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Evidence That the Cannabinoid CB1 Receptor Is a 2-Arachidonoylglycerol Receptor
Journal of Biological Chemistry
An endogenous cannabimimetic molecule, 2-arachidonoylglycerol, induces a rapid, transient increase in intracellular free Ca 2؉ concentrations in NG108 -15 cells through a cannabinoid CB1 receptor-dependent mechanism. We examined the activities of 24 relevant compounds (2-arachidonoylglycerol, its structural analogues, and several synthetic cannabinoids). We found that 2-arachidonoylglycerol is the most potent compound examined so far: its activity was detectable from as low as 0.3 nM, and thedoi:10.1074/jbc.274.5.2794 pmid:9915812 fatcat:bvj2qv5zvjeodet265lefww4vu