To evaluate the influence of 5-thio-D-glucose on irradiation effect after hyperthermia, an experimental study was carried out using a total of 72 m ice. A single dose of 3000 rads was delivered on skin of mouse tail after hypertherrnia with or without intraperitoneal injection of 5-thoi-D-glucose 2 hours before irradiation. The hyperthermia was carried out at 43 0 C for 40 m inutes just before the irradiation. The skin changes of the irradiated mouse tail were observed from 7th to 31 st

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... adiation days, and the scores were analyzed . The results are as follows : 1. Radiation damage on mouse skin increased significantly when radiation was combined with hypert 야 thermia. 2. In the group of 5-thio-D-glucose and irradiation after hyperthermia, radiation damage on mouse skin significantly decreased than in the group without 5-thio-D-glucose. 3. 5-thio-D-g lucose appears to be a potential radioprotective agent in clinical radiotherapy with hyperthermia. F월. 10. Chernica1 structure of 5-thio-D-glucose. A sulfur atorn is replacing the oxygen atorn in pyranose ring. q J n ι