Cases of tuberculosis has gotten worse since results of global surveillance revealed that mycobacterium is resistant to rifampicin and isoniazid. It can cause Loss to Follow-Up among MDR-TB patients. The purpose of this study is Determinants of Loss to Follow-Up among MDR-TB Patients. This research is an analytic observational study with a case control study design with a retrospective approach. Cases were MDR-TB patients who dropped out of treatment as much 27 people, while controls were

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... ts with MDR-TB patients who did not Loss to Follow-Up of treatment as much 83 people. Data analysis was performed by looking at the Odds Ratio value. The result showed that knowledge (OR = 5.28, 95% CI = 1.410347-29.19908), drug side effect (OR = 32.324332, 95% CI = 4.732715-1353.07), family support (OR = 5.01875, 95% CI = 1.602489 -15.57846), social stigma (OR = 6.712963, 95% CI = 1.473798-61.68985) were the determinants of loss to follow up among MDR-TB patients. It can conclude that determinants of loss to follow-up among MDR-TB patients include knowledge, drug side effects, family support, and social stigma.