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Figure 2. Principle of DNA chips. On a solid support, a lot of defined areas are drawn. In each area, known oligonucleotides are immobilised (or directly synthesised). Each area corresponds to one type of oligonucleotide. When DNA chips is put in contact with solution containing single strand DNA to be detected, only strands complementary to fixed oligonucleotides can form a stable hybrid in localised area. The detection of different areas where hybridisation occurred allowed determining thedoi:10.1051/analusis:1999270639 fatcat:l3tqg2cwbnd6nbu5vjuagybmhe