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CCR1 and CCR5 promote hepatic fibrosis in mice
2009
Journal of Clinical Investigation
Hepatic fibrosis develops as a response to chronic liver injury and almost exclusively occurs in a proinflammatory environment. However, the role of inflammatory mediators in fibrogenic responses of the liver is only poorly understood. We therefore investigated the role of CC chemokines and their receptors in hepatic fibrogenesis. The CC chemokines MIP-1α, MIP-1β, and RANTES and their receptors CCR1 and CCR5 were strongly upregulated in 2 experimental mouse models of fibrogenesis.
doi:10.1172/jci37444
fatcat:bfs5ranwjnalnm7qtfp653nxey