An Analysis of Arrhythmias Induced by Ouabain in Intact Dogs

Mario Vassalle, Kalman Greenspan, Brian F. Hoffman
1963 Circulation Research  
Methods The autoiuatieity of the ventricular specialized conducting system was studied by means of vagal stimulation which resulted in either A-V block or cardiac standstill. The rate of ventricular escape during vagal stimulation was taken as a measure of the automaticity of the specialized tissues of the ventricles. Graded vagal stimulation which slowed the sinus rhythm, without suppressing it, also was employed when re-entry type beats were present. The experimental animals were mongrel dogs
more » ... of either sex weighing 9.5 to 21.8 kg. The animals were anesthetized with sodium pentobarbital (30 nig/kg intravenously) and additional amounts of anesthetic were administered intravenously as required. The dogs were placed in supine position. A tracheotomy was performed and a cannula inserted. Blood pressure was recorded through a
doi:10.1161/01.res.13.2.132 pmid:14047639 fatcat:vrgatouysrehbkwqteyw4mtnvy