The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters

Karen L. Huyck, Carolien I.M. Panhuysen, Karen T. Cuenco, Jingmei Zhang, Hilary Goldhammer, Emlyn S. Jones, Priya Somasundaram, Allison M. Lynch, Bernard L. Harlow, Hang Lee, Elizabeth A. Stewart, Cynthia C. Morton
2008 American Journal of Obstetrics and Gynecology  
Objectives-To identify risk factors for uterine leiomyomata (UL) in a racially diverse population of women with a family history of UL and to evaluate their contribution to disease severity and age at diagnosis. Study Design-We collected and analyzed epidemiological data from 285 sister pairs diagnosed with UL. Risk factors for UL-related outcomes were compared among black (n=73) and white (n=212) sister pairs using univariate and multivariate regression models. Results-Black women reported an
more » ... verage age at diagnosis of 5.3 years younger (SE 1.1, p<0.001) and were more likely to report severe disease (OR=5.22, CI 95% 1.99-13.7, p<0.001) than white women of similar socioeconomic status. Conclusions-Self-reported race is a significant factor in the severity of UL among women with a family history of UL. Differences in disease presentation between races likely reflect underlying genetic heterogeneity. The affected sister-pair study design can address both epidemiological and genetic hypotheses about UL. , cmorton@partners.org. Condensation Symptom severity and age at diagnosis of uterine leiomyomata are strongly associated with race in women with a family history of uterine leiomyomata. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers
doi:10.1016/j.ajog.2007.05.038 pmid:18226615 pmcid:PMC2265083 fatcat:sqtmdfl44fh75nqsuqmv2tesz4