Objective: To evaluate the sodium fluoride (NaF) intoxicated kidney function parameters and also assess the ameliorating effects of selenium and curcumin extract. Methods: Mature male mice (weighing 35-45 g) were given intraperitoneally NaF (10.3 mg/kg) and/or selenium (0.5 mg/kg)+curcumin extract (60 mg/kg) daily for 4 weeks. Results: In our study, NaF exposure resulted in an increase in the urea, creatinine, triglycerides, total cholesterol, high density lipoprotein, low density lipoprotein

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... d very low density lipoprotein levels with respect to the control. As a result, NaF induced antioxidant defense system impairment and renal impairment which was reduced by curcumin extract and/or selenium to great extent by the entire restoration of the histological structures. Conclusions: Our study showed that selenium and curcumin extract treatment alleviated NaF intoxication-induced oxidative damage of mice.