Worldwide there was a pandemic of novel corona virus infection in which one of the major concern was the risk of thrombosis and the mortality associated with it. Aim: In this study our aim was to observe the changes in D-dimer levels during disease progression and its correlations with severity of Pneumonia, duration of hospital stay and mortality of COVID-19 patients. Materials & Methods: In this study we reported the clinical, radiological and pathological laboratory results of 432 cases of

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... nfirmed COVID-19 infection. In these patients their clinical presentation, concentration of D-dimer, coagulation parameters, CBC, severity of Pneumonia on HrCT, hospital stay and higher mortality were retrospectively analyzed. Result: All the statistical variables were expressed in % and compared withx 2 test. Out of the 432 cases in 45 cases (10.41%) the D-dimer values were >2.4µg/ml and in 15 cases the value were very high (3.47%). When correlated these patients found to have severe degree of pneumonia, longer hospital stay and higher mortality rate in comparison to patients with D-dimer level of <2.4 µg/ml. Conclusion: D-dimer level could be used as an early marker for the clinical classification, risk stratification and improved management of COVID-19 patients.