Gender Differences in the Level of Antibodies to Measles Virus in Adults

P. Mikhail Kostinov, I. Pavel Zhuravlev, N. Nikolay Filatov, M. Аristitsa Kostinova, B. Valentina Polishchuk, D. Anna Shmitko, V. Cyrill Mashilov, E. Anna Vlasenko, A. Alexey Ryzhov, M. Аnton Kostinov
2021 Vaccines  
Individuals without a protective antibody level are susceptible to measles infection. There are differences in the persistence of antibodies after vaccination and infection, while the impact of gender on this process has not been sufficiently studied. Measles Ig G antibodies were measured in 1742 employees of a large hospital facility—403 men and 1339 women aged from 25 to 67 years; 15% participants had antibody levels less than the protective threshold of ≥0.18 IU/mL. Significant differences
more » ... re found in the age group 40–49, where the level of IgG antibodies to measles among men was higher than among women (1.51 IU/mL (0.41; 3.38) vs. 0.70 IU/mL (0.22;1.98) respectively, (U = 3.2, p = 0,001)); in the age group 60 and older, by contrast, the level of antibodies among women was higher compared to men (3.29 IU/mL (1.72; 4.07) vs. 2.90 IU/mL (1.46; 3.53) respectively (U = 2.2, p = 0.03)). The proportion of seronegative women in the age group 40–49 was significantly higher than of seronegative men: 22 [18–26]% and 11 [6–18]% respectively (χ2 = 7.0, p = 0.001). The revealed gender characteristics that affect persistence of measles immunity may be important in personalization of vaccinal prevention for men and women.
doi:10.3390/vaccines9050494 pmid:34065880 pmcid:PMC8151386 fatcat:hwpez5supngotcwvpyp57u7ffu