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Conserved Regions of Gonococcal TbpB Are Critical for Surface Exposure and Transferrin Iron Utilization
2013
Infection and Immunity
ABSTRACTThe transferrin-binding proteins TbpA and TbpB enableNeisseria gonorrhoeaeto obtain iron from human transferrin. The lipoprotein TbpB facilitates, but is not strictly required for, TbpA-mediated iron acquisition. The goal of the current study was to determine the contribution of two conserved regions within TbpB to the function of this protein. Using site-directed mutagenesis, the first mutation we constructed replaced the lipobox (LSAC) of TbpB with a signal I peptidase cleavage site
doi:10.1128/iai.00280-13
pmid:23836816
pmcid:PMC3754215
fatcat:nvhbpxnsyzaerlcq2x4qj5thw4