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Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its pathological conformational conversion
[article]
2021
bioRxiv
pre-print
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease characterized by the selective death of motor neurons. Misfolded Cu, Zn-superoxide dismutase (SOD1) has been linked to both familial ALS and sporadic ALS. SOD1 fibrils formed in vitro are able to incorporate into cells, transmit intercellularly, and share toxic properties with ALS inclusions. Here we produced amyloid fibrils in vitro from recombinant, full-length apo human SOD1 under semi-reducing conditions
doi:10.1101/2021.12.07.471532
fatcat:4tkbcmgvpvfqdleqyfvy3meilm