Sexual precocity and its treatment

DeAnna B. Brown, Lindsey A. Loomba-Albrecht, Andrew A. Bremer
2013 World Journal of Pediatrics  
Puberty is a complex and dynamic period in development during which individuals transition from the juvenile to adult state. Regulated by multiple genetic and endocrine controls, it is characterized by somatic growth and sexual maturation. Sexual precocity is defined as the appearance of secondary sexual characteristics before the lower limit of the normal age for pubertal onset. Data sources: Based on recent publications and the experience with the disease of our group, we reviewed the normal
more » ... iming and order of puberty, the definition of sexual precocity, the classification of sexual precocity, the differential diagnosis of sexual precocity, variations in pubertal development, the diagnosis of sexual precocity, and the treatment of sexual precocity. Results: Sexual precocity can be classified as either gonadotropin-releasing hormone (GnRH)-dependent or GnRH-independent. Regardless of the etiology, sexual precocity causes increased height velocity, somatic development, and skeletal maturation, which may have profound physical and psychological implications. Conclusions: The treatment of sexual precocity is focused on its cause and must address both its psychosocial and clinical implications. For GnRHdependent precocious puberty, GnRH agonists are the main pharmacological agents used. Alternatively, the treatment of disorders causing GnRH-independent sexual precocity is directed toward the underlying abnormality. World J Pediatr 2013;9(2):103-111
doi:10.1007/s12519-013-0411-7 pmid:23677828 fatcat:4yz47gwjubgq3motdnp7ihfwd4