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Dual-target function validation of single-particle selection from low-contrast cryo-electron micrographs
[article]
2013
arXiv
pre-print
Weak-signal detection and single-particle selection from low-contrast micrographs of frozen hydrated biomolecules by cryo-electron microscopy (cryo-EM) presents a practical challenge. Cryo-EM image contrast degrades as the size of biomolecules of structural interest decreases. When the image contrast falls into a range where the location or presence of single particles becomes ambiguous, a need arises for objective computational approaches to detect weak signal and to select and verify
arXiv:1309.2618v1
fatcat:6lm66ax2pvg4vcnbfokvq3qk7a