Overall Reduced Baseline Lymphocyte Subsets Closely Related to the Poor Prognosis and the Disease Severity in Patients With COVID-19 and Diabetes Mellitus [post]

Dafeng Liu, yong Wang, Bennan Zhao, Lijuan Lan, Yaling Liu, Lei Bao, Hong Chen, Min Yang, Qingfeng Li, Yilan Zeng
2020 unpublished
IntroductionDysregulated host immune response was common in COVID-19. In this study we aimed at the characteristics of lymphocyte subsets and its relationship with the disease progression in COVID-19 patients with or without DM.MethodsThe baseline peripheral lymphocyte and subsets were compared between 55 healthy cases (control group) and 95 confirmed cases with COVID-19 (COVID-19 group), and between COVID-19 patients with and without DM.ResultsThe prevalence of DM in COVID-19 group was 20%,
more » ... 9 group was 20%, and severe cases had higher the prevalence of DM than non-severe cases (P=0.006), moreover significantly poor prognosis and higher severe rate were found in those with DM relative to those without DM (P=0.001,0.003, respectively). In COVID-19 group overall and significant reduced lymphocyte and subsets, especially B and T lymphocytes were found, especially in those with DM. Partial decreased lymphocyte subsets, age and DM closely related with the disease progression and the prognosis.ConclusionsThese findings provide a reference for clinicians that immunomodulatory treatment maybe improve disease progression and prognosis of COVID-19 patients, especially those with DM.
doi:10.21203/rs.3.rs-100003/v1 fatcat:ojmdvdmpjzbohbh3ons2eudnfy