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Meta-Analysis: The Effect of D-Dimer on Mortality in Patients with COVID-19

Yusuf Ryadi, Masters Program in Public Health, Universitas Sebelas Maret, Setyo Sri Rahardjo, Burhannuddin Ichsan, Faculty of Medicine, IPB University, Indonesia, Faculty of Medicine, Universitas Sebelas Maret, Faculty of Medicine, Universitas Sebelas Maret, Faculty of Medicine, Universitas Muhammadiyah Surakarta
2022 Journal of Epidemiology and Public Health  

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The severity of COVID-19 can be detected by examining elevated levels of CRP, ferritin, IL-6 and LDH. Elevated D-dimer levels are often found in patients with severe COVID-19 which can predict the occurrence of ARDS (Acute Respiratory Distress Syndrome) and patient mortality. The purpose of this study was to determine how much influence D-dimer levels had on mortality of COVID-19 patients. Subjects and Method: This study used a systematic review and meta-analysis with following PICO,
more » ... patients with a clinical diagnosis of COVID-19. Intervention: high D-dimer level. Comparison: low D-dimer level. Outcome: mortality. The data used were obtained from scientific research articles from Pubmed, Google Scholar, Science Direct, and Proquest electronic databases with a cohort design in 2020 until 2022 and report on aOR in multivariate analysis. The keywords used in the search for scientific articles were "D-dimer level" OR "D-dimer" AND "COVID-19" AND "mortality". The selection of articles is done by using PRISMA flow diagram. Data were analyzed using Review Manager software version 5.4.1. Results: A total of 12 studies with a cohort design that met the criteria from Asia, America, and Europe were selected for a systematic review and meta-analysis. Based on the meta-analysis, it was found that increased levels of D-dimer (>0.5 g/mL) increased mortality in COVID-19 patients by 6.40 times compared to low levels of D-dimer (≤0.5 g/mL) and was statistically significant (aOR = 6.40; 95% CI= 4.51 to 9.08; p<0.001). Conclusion: Elevated levels of D-dimer may increase mortality risk in COVID-19 patients.
doi:10.26911/jepublichealth.2022.07.04.11 fatcat:l6l5bpb4yve3zkx2n2w3ztq4iq
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Yusuf Ryadi, Masters Program in Public Health, Universitas Sebelas Maret, Setyo Sri Rahardjo, Burhannuddin Ichsan, Faculty of Medicine, IPB University, Indonesia, Faculty of Medicine, Universitas Sebelas Maret, Faculty of Medicine, Universitas Sebelas Maret, Faculty of Medicine, Universitas Muhammadiyah Surakarta. "Meta-Analysis: The Effect of D-Dimer on Mortality in Patients with COVID-19." Journal of Epidemiology and Public Health 7.4 (2022) 552-561