To improve the efficiency of warehouse operations, reasonable optimization of picking operations has become an important task of the modern supply chain. For the purpose of optimization of order picking in warehouses, a new fruit fly optimization algorithm, particle swarm optimization, random weight, and weight decrease model are used to solve the mathematical model. Further optimization is achieved through the analysis of the warehouse shelves and screening of the optimal solution of the

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... g time. In addition, simulation experiments are conducted in the MATLAB environment through programming. The shortest picking time is found out and chosen as an optimized method by taking advantage of the effectiveness of these six algorithms in the picking optimization and comparing the data obtained under the simulation. The result shows that the optimization capacity of RWFOA is better and the picking efficiency is the best.