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Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1
2008
Journal of Lipid Research
Change in phosphoethanolamine pool size in tumor tissues is an important indicator of tumor prognosis and drug therapy efficacy. Phosphoethanolamine is the substrate of the regulatory enzyme CTP:phosphoethanolamine cytidylyltransferase (ECT) in the de novo biosynthesis of phosphatidylethanolamine (PE). Metabolic labeling with [ 14 C]ethanolamine revealed a reduced ECT activity in MCF-7 breast cancer cells, which led to an accumulation of phosphoethanolamine and a decrease in PE synthesis in
doi:10.1194/jlr.m800259-jlr200
pmid:18583706
fatcat:55ezys73gnbgroqze3gckt3nwq