and Objectives: Epidemiological studies have revealed the increased prevalence of spontaneous abortion, stillbirth, and premature babies among women who were exposed to high levels of arsenic in consumable water during their reproductive years. The study explored the fetal toxicity in albino mice inoculated by sodium arsenate and its prevention by Vitamins C & E. Material and Methods: Gravid albino mice of BALB/c strain twenty-four in number were randomly distributed into 4 groups containing 6

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... nimals in each group. Control group 1 was injected with distilled water 0.1ml/kg/day I/P for 18 days. A single dose of sodium arsenate 35mg/kg was injected I/P on 8 th gestational day to groups 2, 3 & 4. Vitamins C and E 9 mg/kg/day and 15 mg/kg/day respectively, were given by intraperitoneal injections to groups 3 and 4 starting from 8 th gestational day and continued for the rest of the pregnancy period. The fetal resorption sites were counted both early & late, litter sizes were logged. Morphological malformations were examined grossly. Results: An increased incidence of abortion, fetal resorptions, and a significant decrease in litter size were manifested in group 2. Groups 3 & 4 showed noticeable improvement in litter size and the number of fetal resorptions were reduced. There was a statistically significant difference in means among the groups (p<0.000). Conclusions: The results exposed the antioxidant potential of ascorbic acid and alpha-tocopherol in inhibiting the arsenic borne fetal toxicity in mice.