NEW ADDITIVE TECHNOLOGIES FOR FORMING COMPLEX BONE STRUCTURES FOR MEDICAL AND BIOLOGICAL APPLICATIONS
НОВЫЕ АДДИТИВНЫЕ ТЕХНОЛОГИИ ФОРМИРОВАНИЯ СЛОЖНЫХ КОСТНЫХ СТРУКТУР ДЛЯ МЕДИКО-БИОЛОГИЧЕСКИХ ПРИМЕНЕНИЙ

Vladimir N. Gorshenev, Emanuel Institute of Biochemical Physics of RAS, Maya Yu. Ziangirova, Vladimir V. Kolesov, Lyudmila M. Krasnopolskaya, Alexander A. Prosvirin, Andrey T. Teleshev, Gause Institute of New Antibiotics, Kotelnikov Institute of Radioengineering and Electronics of RAS, Gause Institute of New Antibiotics, Yevdokimov Moscow State University of Medicine and Dentistry, Moscow Pedagogical State University
2019 Radioelectronics Nanosystems Information Technologies  
A synthesis of nanosized hydroxyapatite by the exchange reaction between diammonium phosphate and calcium nitrate under conditions of mechano-acoustic processing of the reaction mixture was developed. Methods are proposed for purifying hydroxyapatite from by-products. By dispersing raw materials of animal origin, a protein hydrosol was obtained in the medium of which hydroxyapatite was synthesized and a collagen-calcium-phosphate composite was obtained. Methods for the formation of porous
more » ... ion of porous collagen-calcium-phosphate composites, among which the effect of microwave radiation, are considered. It is shown that based on the developed biocompositions: calcium phosphate pastes, compositions from thermoplastic biodegradable polymers, non-woven fibrous materials, fabric-engineering constructions with an adjustable architecture can be made to solve various biomedical problems. The creation of three-dimensional structures capable of performing the functions of a particular natural tissue of the body, based on a combination of cells and scaffolds (three-dimensional structures, matrix, scaffold), as well as other factors affecting cell growth, their differentiation and organization of the extracellular matrix, is an important task of the tissue engineering.
doi:10.17725/rensit.2019.11.369 fatcat:yxuhyf5gvfcsnkafcuu6nomncy