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Limonoids and carbazole alkaloids from the twigs of Chalcas siamensis Tanaka

Sirada Boonyaketgoson, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Kongkiat Trisuwan
2020 Figshare  

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One new limonoid, named siamensinolide (1), together with two known limonoids (2 and 3) and eight carbazole alkaloids (4–11) were isolated from the twigs of Chalcas siamensis Tanaka. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. O-methylclausenolide (2) displayed strong cytotoxicity against A2780 cell lines with the IC50 value of 9.2 µM, while clausenolide (3) exhibited strong antibacterial activity against methicillin-resistant Staphylococcus aureus with the MIC value of 0.5 µg/mL.
doi:10.6084/m9.figshare.12366647 fatcat:tbilhfjwojd5zd56qyipr4mx4u
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Sirada Boonyaketgoson, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Kongkiat Trisuwan. "Limonoids and carbazole alkaloids from the twigs of Chalcas siamensis Tanaka." Figshare (2020)