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Pneumococcal cell wall induces meningeal inflammation in rabbits injected intracisternally with >10 5 cell equivalents. Both of the major cell wall components, teichoic acid and peptidoglycan, contribute to this inflammatory activity although responses differ depending on the chemical nature, size, and complexity of these fractions. Challenge with teichoic acid (membrane or wall associated) results in greater inflammation at 5 hr than at 24 hr. Degraded teichoic acid is inactive. In contrast,doi:10.1093/infdis/151.5.859 pmid:3989321 fatcat:zlrvpubhzva7lkd2zoq2avr67u