Aim: To evaluate the effect of calcium hydroxide (CH) and triple antibiotic paste (TAP), on the push-out bond strength of ProRoot MTA and Biodentine. Methodology: Root canals of 120 human teeth were instrumented using rotary files. To obtain a standard diameter of 1.5 mm,the roots were instrumented to a #6 Peeso reamer. The reamers were passed 1 mm beyond apex to simulate open apices. The roots were randomly assigned into following groups: Group 1: CH; Group 2: TAP; Group 3: no medicament

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... ol). The medicaments were removed after 3 weeks. Thereafter, the specimens were divided into two subgroups according to the calcium silicate-based cement applied (n = 20): (i) ProRoot MTA (Dentsply Tulsa Dental, USA) and (ii) Biodentine (Septodont, France). Push-out test was performed, and the data were analysed statistically using one-way ANOVA and Tukey's post hoc test. Results: In both MTA and Biodentine groups, pairwise comparisons between medicaments showed similar values to the control group (P > 0.05). Overall, there was a predominance of cohesive failures between root dentin and cements. Conclusion: Biodentine and ProRoot MTA showed similar bond strength values, and prior application of the TAP and CH did not affect the bond strength significantly.