A NEW STRATEGY OF GEOMETRICAL BICLUSTERING FOR MICROARRAY DATA ANALYSIS

HONGYA ZHAO, ALAN W. C. LIEW, HONG YAN
2007 Proceedings of the 5th Asia-Pacific Bioinformatics Conference  
In this paper, we present a new biclustering algorithm to provide the geometrical interpretation of similar microarray gene expression profiles. Different from standard clustering analyses, biclustering methodology can perform simultaneous classification on the row and column dimensions of a data matrix. The main object of the strategy is to reveal the submatrix, in which a subset of genes exhibits a consistent pattern over a subset of conditions. However, the search for such subsets is a
more » ... ationally complex task. We propose a new algorithm, based on the Hough transform in the column-pair space to perform pattern identification. The algorithm is especially suitable for the biclustering analysis of large-scale microarray data. Our simulation studies show that the method is robust to noise and computationally efficient. Furthermore, we have applied it to a large database of gene expression profiles of multiple human organs and the resulting biclusters show clear biological meanings.
doi:10.1142/9781860947995_0008 fatcat:edyoj4s3szeg7otsx3v2ngtxpq