Guidelines for the management and treatment of periodic fever syndromes familial Mediterranean fever

Maria Teresa R.A. Terreri, Wanderley Marques Bernardo, Claudio Arnaldo Len, Clovis Artur Almeida da Silva, Cristina Medeiros Ribeiro de Magalhães, Silvana B. Sacchetti, Virgínia Paes Leme Ferriani, Daniela Gerent Petry Piotto, André de Souza Cavalcanti, Ana Júlia Pantoja de Moraes, Flavio Roberto Sztajnbok, Sheila Knupp Feitosa de Oliveira (+4 others)
2016 Revista Brasileira de Reumatologia (English Edition)  
r e v b r a s r e u m a t o l . 2 0 1 6;5 6(1):37-43 w w w . r e u m a t o l o g i a . c o m . b r a b s t r a c t Objective: To establish guidelines based on scientific evidence for the management of familial Mediterranean fever. Description of the evidence collection method: The Guideline was prepared from 5 clinical questions that were structured through PICO (Patient, Intervention or indicator, Comparison and Outcome), to search key primary scientific information databases. After defining
more » ... e potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. Results: 10,341 articles were retrieved and evaluated by title and abstract; from these, 46 articles were selected to support the recommendations. séricos de SAA podem ser especialmente úteis no monitoramento da eficácia do tratamento; 4. A colchicina é a terapia de escolha tendo demonstrado eficácia na prevenção dos episódios inflamatórios agudos e progressão para amiloidose em adultos; 5. Com base na informação disponível, a utilização de medicamentos biológicos parece ser alternativa para pacientes com FFM que não respondem ou que são intolerantes à terapia com colchicina.
doi:10.1016/j.rbre.2015.08.019 pmid:27267332 fatcat:p7vz5xbaznaxjdbeojs766q6ci