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r e v b r a s r e u m a t o l . 2 0 1 6;5 6(1):37-43 w w w . r e u m a t o l o g i a . c o m . b r a b s t r a c t Objective: To establish guidelines based on scientific evidence for the management of familial Mediterranean fever. Description of the evidence collection method: The Guideline was prepared from 5 clinical questions that were structured through PICO (Patient, Intervention or indicator, Comparison and Outcome), to search key primary scientific information databases. After definingdoi:10.1016/j.rbre.2015.08.019 pmid:27267332 fatcat:p7vz5xbaznaxjdbeojs766q6ci