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Deficiency of IKKɛ inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice
2014
International Journal of Molecular Medicine
Immune response and metabolic regulation have been recognized as a central homeostatic mechanism, the dysfunction of which can trigger a cluster of chronic metabolic disorders, particularly obesity, type Ⅱ diabetes and cardio vascular disease. Serine/threonine kinase IκB kinase (IKK) ε is a multifunctional regulator that participates in immune regulation, cell proliferation and transformation, and oncogenesis. In the present study, we investigated the role of IKKε in cardiovascular disorders
doi:10.3892/ijmm.2014.1746
pmid:24789209
fatcat:ttmrswcbkzby3asggm7vpkgwsy