Deficiency of IKKɛ inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice

CHANGCHUN CAO, LIANGPENG LI, WEN CHEN, YIFAN ZHU, YONGCHAO QI, XIAODI WANG, XIN WAN, XIN CHEN
2014 International Journal of Molecular Medicine  
Immune response and metabolic regulation have been recognized as a central homeostatic mechanism, the dysfunction of which can trigger a cluster of chronic metabolic disorders, particularly obesity, type Ⅱ diabetes and cardio vascular disease. Serine/threonine kinase IκB kinase (IKK) ε is a multifunctional regulator that participates in immune regulation, cell proliferation and transformation, and oncogenesis. In the present study, we investigated the role of IKKε in cardiovascular disorders
more » ... scular disorders using murine models of apolipo protein Edeficient [ApoE(/)] mice and ApoE/IKKε double-knockout [ApoE(/)/IKKε(/)]mice, which were fed a normal diet (ND) and high-fat diet (HFD) for 12 weeks, respectively.
doi:10.3892/ijmm.2014.1746 pmid:24789209 fatcat:ttmrswcbkzby3asggm7vpkgwsy