Structural insights into mode of actions of novel natural Mycobacterium protein tyrosine phosphatase B inhibitors

Jaspreet Kaur Dhanjal, Sonam Grover, Sudhanshu Sharma, Ajeet Singh, Abhinav Grover
2014 BMC Genomics  
Tuberculosis has become a major health problem being the second leading cause of death worldwide. Mycobacterium tuberculosis secretes a virulence factor, protein tyrosine phosphatase B (mPTPB) in the cytoplasm of host macrophage which suppresses its natural innate immune response and helps the pathogen survive and proliferate in the phagosome. The present study aims at indentifying potent inhibitors of mPTPB by using computational approaches of ligand based molecular modeling and docking studies.
doi:10.1186/1471-2164-15-s1-s3 pmid:24564493 pmcid:PMC4046716 fatcat:ecf6fryoxjgdbd6kztgbnfmeke