Aquerium: A web application for comparative exploration of domain-based protein occurrences on the taxonomically clustered genome tree

Ogun Adebali, Igor B. Zhulin
2016 Proteins: Structure, Function, and Bioinformatics  
Gene duplication and loss are major driving forces in evolution. While many important genomic resources provide information on gene presence, there is a lack of tools giving equal importance to presence and absence information as well as web platforms enabling easy visual comparison of multiple domain-based protein occurences at once. Here, we present Aquerium, a platform for visualizing genomic presence and absence of biomolecules with a focus on protein domain architectures. The web server
more » ... ers advanced domain organization querying against the database of pre-computed domains for ~26000 organisms and it can be utilized for identification of evolutionary events, such as fusion, disassociation, duplication and shuffling of protein domains. The tool also allows alternative inputs of custom entries or BLASTP results for visualization. Aquerium will be a useful tool for biologists who perform comparative genomic and evolutionary analyses. The web server is freely accessible at http://aquerium.utk.edu.
doi:10.1002/prot.25199 pmid:27802571 pmcid:PMC5167639 fatcat:sjtknbat4jdllm4tvvpofd4w7q