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Trans-genetic effects of circular RNA expression quantitative trait loci and potential causal mechanisms in autism
[post]
2021
unpublished
Genetic risk variants and transcriptional expression changes in autism spectrum disorder (ASD) have been widely identified, but their causal relationship is largely unknown. Circular RNAs (circRNAs) are abundant in brain and often serve as upstream regulators of mRNAs. By integrating RNA-sequencing with genotyping data from autistic brains, we accessed expression quantitative trait loci (eQTL) of circRNAs (circQTLs) that influenced expression of distant genes (trans-eGenes) and constructed
doi:10.21203/rs.3.rs-155043/v1
fatcat:46vh6g2krvatjf7puzthkx7zxq