*Corresponding Antidiabetic Activity Of Annona squamosa L. In Experimental Induced Diabetic Rats

Ranveer Tomar, Ranveer Tomar, Siddharaj Sisodia
2012 International Journal of Pharmaceutical & Biological Archives   unpublished
The principle aim of present investigation is to evaluate antidiabetic activity of hydroalcoholic extract of Annona squamosa Linn. in experimentally induced diabetic rat model. Treatment with Annona squamosa extract and Glibenclamide at a dose of 350mg/kg and 5mg/kg respectively for 28 days, after induction of diabetes by Streptozotocin, caused significant reduction in blood serum glucose, lipid profiles like serum cholesterol and triglycerides but significant increase in HDL and body weight in
more » ... and body weight in diabetic rats compared to untreated group. Furthermore, the extract showed significant reduction in blood serum glucose after glucose loading compared to control group in oral glucose tolerance test performed in normal rats. The antidiabetic activity of extract is found comparable than Glibenclamide. Thus, leaves of Annona squamosa Linn. can be used as potential antidiabetic drug.