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Network-based method for drug target discovery at the isoform level
2019
Scientific Reports
Identification of primary targets associated with phenotypes can facilitate exploration of the underlying molecular mechanisms of compounds and optimization of the structures of promising drugs. However, the literature reports limited effort to identify the target major isoform of a single known target gene. The majority of genes generate multiple transcripts that are translated into proteins that may carry out distinct and even opposing biological functions through alternative splicing. In
doi:10.1038/s41598-019-50224-x
pmid:31554914
pmcid:PMC6761107
fatcat:n22wlxq5ybf67gh6bp3eft4iai