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Scaling probabilistic models of genetic variation to millions of humans
2016
Nature Genetics
One of the major goals of population genetics is to quantitatively understand variation of genetic polymorphisms among individuals. To this end, researchers have developed sophisticated statistical methods to capture the complex population structure that underlies observed genotypes in humans, and such methods have been effective for analyzing modestly sized genomic data sets. However, the number of genotyped humans has grown significantly in recent years, and it is accelerating. In aggregate
doi:10.1038/ng.3710
pmid:27819665
pmcid:PMC5127768
fatcat:xh6w5ipdmjfc5ic33j72tath3u