A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Peridinin suppresses zinc-enhanced M1 phenotype of microglia via inhibition of ROS generation
2019
Proceedings for Annual Meeting of The Japanese Pharmacological Society
Aim] Extracellular zinc enhances pro-inflammatory cytokines secretion from M1 microglia via reactive oxygen species (ROS) generation. Here, we examined the effect of peridinin, a carotenoid in dinoflagellates, on the zincenhanced inflammatory M1 phenotype. [Methods] M1 polarization of mouse microglia prepared was induced by lipopolysaccharide after ZnCl 2 treatment in the presence of peridinin, and cytokines secretion were assessed by ELISA. In addition, ROS detection assay and HPLC analysis
doi:10.1254/jpssuppl.92.0_2-o-03
fatcat:gi4bflrmwjbkjknabdrfbulsbu