OphthatomeTM: An integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic [post]

Praveen Raj, Sushma Tejwani, Dandayudhapani Sudha, Muthu Narayanan B, Chandrasekar Thangapandi, Sankar Das, Somasekar J, Susmithasane Mangalapudi, Durgesh Kumar, Narendra Pindipappanahalli, Rohit Shetty, Arkashubra Ghosh (+3 others)
2020 unpublished
Background: Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of disease progression and management, disease surveillance, impact on public health and research. Although, the electronic medical records (EMR) system is the digital storehouse of rich medical data of a large patient cohort collected over many years, the data lack sufficient structure to be of
more » ... cal value for applying deep learning methods and advanced analytics to improve disease management at an individual patient level or for the discipline in general. Ophthatome TM captures data contained in retrospective electronic medical records between September 2012 and January 2018 to facilitate translational vision research through a knowledgebase of eye diseases. Methods: The electronic medical records data from Narayana Nethralaya recorded in the MS-SQL database was mapped and programmatically transferred to MySQL. The captured data was manually curated to preserve data integrity and accuracy. The data is stored in MySQL database management system for ease of visualization, advanced search functions and other knowledgebase applications. Results: Ophthatome TM is a comprehensive and accurate knowledgebase of ophthalmic diseases containing curated clinical, treatment and imaging data of 581,466 ophthalmic cases from the Indian population, recorded between September 2012 and January 2018. Ophthatome TM provides filters and Boolean searches with operators and modifiers that allow selection of specific cohorts covering 524 distinct ophthalmic disease types and 1800 disease sub-types across 35 different anatomical regions of the eye. The availability of longitudinal data for about 300,000 subjects provides additional opportunity to perform clinical research on disease progression and management including drug response and treatment outcome. The knowledgebase captures eye diseases in a genetically diverse population providing opportunity to study genetic and environmental factors contributing to or influencing eye diseases. Conclusion: Ophthatome TM will accelerate clinical, genomic, pharmacogenomic and advanced translational research on ophthalmic diseases.
doi:10.21203/rs.3.rs-35644/v2 fatcat:smkk33ydm5gfraujejckcrd7dm