The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation

Youngmi Kim, Sangkyung Eom, Deokbum Park, Hyuna Kim, Dooil Jeoung
2015 Frontiers in Immunology  
We previously reported the anti-allergic effect of high molecular weight form of hyaluronic acid (HMW-HA). In doing so, HA targets CD44 and inhibits FcεRI signaling and cross-talk between epidermal growth factor receptor (EGFR) and FcεRI. We previously reported the role of histone deacetylases (HDACs) in allergic inflammation and allergic inflammationpromoted enhanced tumorigenic potential. We reported regulatory role of HA in the expression of HDAC3. In this review, we will discuss molecular
more » ... chanisms associated with anti-allergic effect of HA in relation with HDACs. The role of microRNAs (miRNAs) in allergic inflammation has been reported. We will also discuss the role of miRNAs in allergic inflammation in relation with HA-mediated anti-allergic effects.
doi:10.3389/fimmu.2015.00210 pmid:25983734 pmcid:PMC4415435 fatcat:r4mo3uz5gzcmvelz6fev5halga