CGMP manufacture of the multipotent adult progenitor cell (MAPC) and strategy for clinical testing

J.E. Wagner, C.M. Verfaillie
2004 Biology of Blood and Marrow Transplantation  
180 revealed no differences except a significantly greater risk of viral infections in TCD recipients from day 0-42 (TCD vs BM RR 3.5, p ϭ 0.02). After day 180, TCD recipients had the greatest infection risk, whereas UCB recipients had the lowest risk TCD vs BM RR 3.1, p ϭ 0.03; UCB vs BM RR 0.5, p ϭ 0.23). Multivariate Cox regression analysis revealed that age Ն8 years, TCD, and severe acute GVHD were each associated with increased infection risk. These data suggest that the immune
more » ... immune reconstitution after UCB transplantation is superior to that seen with TCD, and is as good as with unmanipulated BM.
doi:10.1016/j.bbmt.2004.06.029 fatcat:vuqfdjohp5dzzngavpqyvws4nu