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TEL/AML1 overcomes drug resistance through transcriptional repression of multidrug resistance-1 gene expression
Molecular Cancer Research
The t(12;21)(p12;q22) chromosomal aberration, which is frequently observed in pediatric precursor B-cell acute lymphoblastic leukemia (ALL), generates the TEL/AML1 chimeric gene and protein. TEL/AML1-positive ALL has a favorable prognosis, and one possible reason is that this subtype of ALL rarely shows drug resistance. AML1/ETO, another AML1-containing chimeric protein, has been shown to transcriptionally repress the activity of the multidrug resistance-1 (MDR-1) gene promoter; thus, wepmid:15235109 fatcat:qjc3as72vzdlbo3xsigdyb7hii