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EGF receptor–mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling
Journal of Cell Biology
Excessive accumulation of collagen leads to fibrosis. Integrin α1β1 (Itgα1β1) prevents kidney fibrosis by reducing collagen production through inhibition of the EGF receptor (EGFR) that phosphorylates cytoplasmic and nuclear proteins. To elucidate how the Itgα1β1/EGFR axis controls collagen synthesis, we analyzed the levels of nuclear tyrosine phosphorylated proteins in WT and Itgα1-null kidney cells. We show that the phosphorylation of the RNA-DNA binding protein fused in sarcoma (FUS) isdoi:10.1083/jcb.202001120 pmid:32678881 fatcat:3cf5z5ibcbbuxn5bstris36zm4