Effect of Febuxostat on Blood Pressure in Hyperuricemic Patients: A protocol for a systematic review and Meta-analysis [report]

Jia Yao, Xiaoyan Shi, Simin Fan, Yang Gao, Hengchang Hu, PanPan Wang, Qiu Chen
2020 unpublished
Review question / Objective: Whether febuxostat could reduce systolic blood pressure in hyperuricemic patients? Whether febuxostat could reduce diastolic blood pressure in hyperuricemic patients? Whether febuxostat could reduce the serum creatinine level in hyperuricemic patients? Whether febuxostat could reduce the eGFR in hyperuricemic patients? Condition being studied: In recent years, a series of RCTs have been conducted to clarify whether febuxostat could also lower blood pressure or
more » ... d pressure or influence the natural history of hypertension. However, results of these RCTs remain controversial with some studies reported positive results, others found it had no significant effect. A systematic review and meta-analysis would be appropriate to resolve the current controversy and reach a conclusive result. Thus, the aim of this systematic review and meta-analysis was to evaluate the effect of febuxostat on BP in hyperuricemic patients. And such a study may find a new therapeutic option, that of control of a biochemical cause of hypertension. INPLASY registration number: This protocol was registered with the International Platform of Registered Systematic Review and Meta-Analysis Protocols (INPLASY) on 09 May 2020 and was last u p d a t e d o n 0 9 M a y 2 0 2 0 ( r e g i s t r a t i o n n u m b e r INPLASY202050031).
doi:10.37766/inplasy2020.5.0031 fatcat:mek7o4qbmjglle6f6gfsbhwl4a