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Terezine E, bioactive prenylated tryptophan analogue from an endophyte of Centaurea stoebe

Randa Abdou, Samah Shabana, Mostafa E. Rateb
2018 Figshare  

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Fungal endophytes are considered promising sources of new bioactive natural products. In this study, a Mucor sp. has been isolated as an endophyte from the medicinal plant Centaurea stoebe. Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative
more » ... against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains.
doi:10.6084/m9.figshare.6953375.v1 fatcat:gpswebpsofb35fyqjut4iuxtf4
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Randa Abdou, Samah Shabana, Mostafa E. Rateb. "Terezine E, bioactive prenylated tryptophan analogue from an endophyte of Centaurea stoebe." Figshare (2018)