Cough mixtures are frequently prescribed for cough associated with upper respiratory diseases. Many different cough mixture combinations are available making an informed, therapeutic sound choice, can be challenging to a pharmacist. Supportive evidence on the efficacy of cough mixtures is not yet convincing, cough mixtures alleviates symptoms of colds and flu. This review article aims to provide the pharmacist with knowledge and skills to make an appropriate informed choice of drug individualised for the right patient, at the right time.