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Transcription factors (TFs) are regulatory proteins that bind DNA in promoter regions of the genome and either promote or repress gene expression. Here we predict analytically that enhanced homo-oligonucleotide sequence correlations, such as poly(dA:dT) and poly(dC:dG) tracts, statistically enhance non-specific TF-DNA binding affinity. This prediction is generic and qualitatively independent of microscopic parameters of the model. We show that non-specific TF binding affinity is universallydoi:10.1016/j.bpj.2011.04.037 pmid:21723826 pmcid:PMC3127192 fatcat:wa3ccoyu4zbtbd2yzggldhnhoe