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2D-QSAR STUDY ON SOME NOVEL 6-ACETYL-3-[3-CHLORO-2-(SUBSTITUTED)-4-OXOAZETIDIN-1-YL]-2, 5-DIPHENYL-2, 3-DIHYDROPYRIDINE-4-CARBONITRILE ANALOGUES AS AN ANTIFUNGAL ACTIVITY
unpublished
Carbonitrile were screened for their antifungal activity against fungi Candida albicans. These compounds have showed moderate and very good antifungal activity. The Quantitative Structure Activity-Relationships (QSAR) study on the pyridine series was made using lipophilic, electronic and steric parameters. Several statistical expressions were developed and best models were validated. The studies confirm that the antifungal activity is dependent on selected lipophilic and electronic parameters.
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