Antibiotics and the Postburn Hypermetabolic Response [report]

J. P. Waymack
1990 unpublished
DTIC SELECTEOf SJAN D 199I This docuraneit has bean aPproved x:, ptbi.l o jtoa and oule; it3 92-01498 11IIIIIIIlIIIlliii 111l ii)1liiilll Antibiotics and the Postburn Hypermetabolic Response J. PAUL WAYMACK, M.D., Sc.D. Severe burn injury has been de-nmented to significantly increase resting metabolic energy expenditure. I increase in metabolic rate appears to be possibly correlated with the degree of burn wound colonization and infection with bacteria. Prevention of such colonization and
more » ... ion through the use of topical antimicrobial agents appears to decrease the metabolic alterations resulting from burn injury. These. findings indicate that appropriate use of topical antibact. -"P agents may decrease the metabolic demands seen in burned patier u P • -i tduced translocation of intestinal bacteria has also been hypott teo~d c co,-tl-bute to thie postburn hypermetabolic response. Attempts aW preventing this entity in a burned guinea pig model through the use of seleo. tive decontamination of the digestive tract by the administration of enteral ar aibiotics have failed to demonstrate any measurable effect. Major thermal injuries result in marked alterations in any disease process. They in" 1 , de chronic increases in metabolic and hemodynamic function in burn victims resting metabolic energy expenditure, body temperature, (22): the changes are among the most profound seen with respiratory rate, and cardiac rate, which can be further exaggerated by the presence of superimposed infections. Address for reprints: Library Branch, U.S. Army Institute of Sur-This paper reviews the etiology of these alterations with gical Research, Fort Sam Houston, TX 78234. special reference to the contribution of bacteria to the 2 1 16 098 Vol. 30, No. 12 Supplement Advances in Understanding Trauma and Burn Injury S31
doi:10.21236/ada245303 fatcat:qxd6nu7i35ddtoam2iq2r3esgm