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Mining the tissue-tissue gene co-expression network for tumor microenvironment study and biomarker prediction
2013
BMC Genomics
Recent discovery in tumor development indicates that the tumor microenvironment (mostly stroma cells) plays an important role in cancer development. To understand how the tumor microenvironment (TME) interacts with the tumor, we explore the correlation of the gene expressions between tumor and stroma. The tumor and stroma gene expression data are modeled as a weighted bipartite network (tumor-stroma coexpression network) where the weight of an edge indicates the correlation between the
doi:10.1186/1471-2164-14-s5-s4
pmid:24564578
pmcid:PMC3852209
fatcat:aiwj2elxafckhp3dr7u37asqm4