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Recebido em 3/8/07; aceito em 17/12/07; publicado na web em 4/9/08 STIR-BAR SORPTIVE EXTRACTION FOR DRUGS ANALYSIS IN BIOLOGICAL FLUIDS. A novel solventless sample preparation, stir-bar sorptive extraction (SBSE), for extraction, and sample enrichment of organic compounds from biological fluids, is described in this manuscript from principle to applications. The SBSE is based on sorptive extraction, whereby the compounds are extracted into a polymer coating, polydimethylsiloxane (PDMS), on adoi:10.1590/s0100-40422008000700037 fatcat:on6dmaytrrc6da5tdfegmgytlm