Somatomedin activity and diabetic control in children with insulin-dependent diabetes
To test the hypothesis that somatomedin activity is influenced by diabetes and its metabolic regulation, the relationship between somatomedin activity and diabetic control as assessed by hemoglobin A 1C was investigated in 40 children with insulin-dependent diabetes. An inverse correlation between hemoglobin A 1c and serum somatomedin activity was statistically significant. The data suggest that abnormalities of linear growth, which can occur in children with poorly controlled diabetes, may
... d diabetes, may involve abnormalities in net somatomedin activity. DIABETES 28:952-954, October 1979. G rowth impairment may complicate diabetes in children, 1 " 3 particularly when metabolic control is poor, 2 -4 but the mechanism of growth retardation is obscure. There is evidence that hormonal/nutritional contributions to growth are mediated in part by the stimulation of growth cartilage by somatomedins, 5 ' 6 and our recent studies support a major role for insulin in the regulation of circulating somatomedin activity. Rats with streptozotocin-induced diabetes have decreased somatomedin activity and poor growth, 7 -8 with an inverse correlation between somatomedin activity and indices of diabetic control. 8 Previous reports differ as to whether or not somatomedin activity is related to diabetic control in humans, 9 " 12 possibly due in part to lack of suitable markers of chronic metabolic control. Because measurements of hemoglobin A 1c (HbA 1c ) appear to provide an improved index of long-term glucose control, 13 -14 in these studies we compared levels of somatomedin activity with HbA 1c in children with insulin-dependent diabetes (IDD).