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DNA and Cell Biology
The binding of vincristine with DNA has been investigated using Fourier transform infrared spectroscopy. Various changes in the double helical structure of DNA after addition of vincristine have been examined. It is evident from Fourier transform infrared results that vincristine-DNA interaction occurs through guanine and cytosine base pairs. External binding of vincristine with phosphate backbone of the DNA is also observed. Vincristine perturbs guanine band at 1714 cm À1 , cytosine band atdoi:10.1089/dna.2010.1035 pmid:20662555 fatcat:2nigchx77jhz5mr2cgoecqwbky